Publication: Interleukin-34-dependent perivascular macrophages promote vascular function in the brain
Interleukin-34-dependent perivascular macrophages promote vascular function in the brain
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Van Hove, H., Glück, C., Mildenberger, W., Petrova, E., Maheshwari, U., Häne, P., Kreiner, V., Bijnen, M., Mussak, C., Utz, S. G., Droux, J., Ingelfinger, F., Ashworth, C., Stifter, S. A., Roussel, E., Lelios, I., Vermeer, M., Huang, S.-F., Zhou, Q., … Greter, M. (2025). Interleukin-34-dependent perivascular macrophages promote vascular function in the brain. Immunity, 58(5), 1289-1305.e8. https://doi.org/10.1016/j.immuni.2025.04.003
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The development of most macrophages depends on the colony-stimulating factor 1 (CSF-1) receptor, which has two ligands: CSF-1 and interleukin-34 (IL-34). While IL-34 is required for the homeostasis of microglia, the parenchymal macrophages in the central nervous system (CNS), it is unclear whether brain border-associated macrophages (BAMs) also depend on this cytokine. Here, we demonstrated that the embryonic development of murine BAMs in the choroid plexus, leptomeninges, and perivascular spaces required CSF-1, while IL-34 was critic
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- Van Hove, Hannah
- Glück, Chaim
- Mildenberger, Wiebke
- Petrova, Ekaterina
- Maheshwari, Upasana
- Häne, Philipp
- Kreiner, Victor
- Bijnen, Mitchell
- Mussak, Caroline
- Utz, Sebastian G
- Droux, Jeanne
- Ingelfinger, Florian
- Ashworth, Christian
- Stifter, Sebastian A
- Roussel, Elsa
- Lelios, Iva
- Vermeer, Marijne
- Huang, Sheng-Fu
- Zhou, Quanyu
- Chen, Zhenyue
- Calvet, Charlotte
- Bourgeois, Soline
- Schaffenrath, Johanna
- Razansky, Daniel
- Juang, Jean X
- Asano, Kenichi
- Pelczar, Pawel
- Mundt, Sarah
- Weber, Bruno
- Wegener, Susanne
- Tugues, Sonia
- Stockmann, Christian
- Keller, Annika
- El Amki, Mohamad
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Van Hove, H., Glück, C., Mildenberger, W., Petrova, E., Maheshwari, U., Häne, P., Kreiner, V., Bijnen, M., Mussak, C., Utz, S. G., Droux, J., Ingelfinger, F., Ashworth, C., Stifter, S. A., Roussel, E., Lelios, I., Vermeer, M., Huang, S.-F., Zhou, Q., … Greter, M. (2025). Interleukin-34-dependent perivascular macrophages promote vascular function in the brain. Immunity, 58(5), 1289-1305.e8. https://doi.org/10.1016/j.immuni.2025.04.003
