Publication: An Automatable Hydrogel Culture Platform for Evaluating Efficacy of Antibody-Based Therapeutics in Overcoming Chemoresistance
An Automatable Hydrogel Culture Platform for Evaluating Efficacy of Antibody-Based Therapeutics in Overcoming Chemoresistance
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Kletzmayr, A., Clement Frey, F., Zimmermann, M., Eberli, D., & Millan, C. (2020). An Automatable Hydrogel Culture Platform for Evaluating Efficacy of Antibody-Based Therapeutics in Overcoming Chemoresistance. Biotechnology Journal, 15(5), e1900439. https://doi.org/10.1002/biot.201900439
Abstract
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Abstract
The microenvironment plays a major role in conferring chemoresistance to cancer cells. In order to better inform clinical response to chemoresistance, preclinical models that recapitulate its hallmark features are needed to enable screening for resistance-specific therapeutic targets. A novel platform for seeding cancer cells in 3D hydrogels is presented utilizing derivatives of chitosan and alginate that, critically, is amenable to high throughput screening: cell seeding in hydrogels, media changes, dosing of anticancer compounds, an
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Creators (Authors)
- Kletzmayr, Anna
- Clement Frey, Flurina
- Zimmermann, Miriam
- Eberli, Daniel
- Millan, Christopher
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Citations
Kletzmayr, A., Clement Frey, F., Zimmermann, M., Eberli, D., & Millan, C. (2020). An Automatable Hydrogel Culture Platform for Evaluating Efficacy of Antibody-Based Therapeutics in Overcoming Chemoresistance. Biotechnology Journal, 15(5), e1900439. https://doi.org/10.1002/biot.201900439
