Publication: Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers
Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers
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Pellegrini, G., Starkey Lewis, P. J., Palmer, L., Hetzel, U., Goldring, C. E., Park, B. K., Kipar, A., & Williams, D. P. (2013). Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers. Toxicology, 314(2–3), 262–266. https://doi.org/10.1016/j.tox.2013.06.003
Abstract
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Abstract
Polyethylene glycols (PEGs) are commonly employed as excipients in preclinical studies and in vitro experiments to dissolve poorly hydrosoluble drugs. Their use is generally considered safe in both animals and humans; however, limited data is available concerning the safety of PEGs when administered parenterally. The results of our investigation demonstrate that PEG-400 can have an irritant effect on serosal surfaces and causes subcapsular hepatocellular necrosis in mice when administered intraperitoneally at a high dose (4mL/kg). Acc
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- Pellegrini, G
- Starkey Lewis, P J
- Palmer, L
- Hetzel, U
- Goldring, C E
- Park, B K
- Kipar, A
- Williams, D P
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Pellegrini, G., Starkey Lewis, P. J., Palmer, L., Hetzel, U., Goldring, C. E., Park, B. K., Kipar, A., & Williams, D. P. (2013). Intraperitoneal administration of high doses of polyethylene glycol (PEG) causes hepatic subcapsular necrosis and low-grade peritonitis with a rise in hepatic biomarkers. Toxicology, 314(2–3), 262–266. https://doi.org/10.1016/j.tox.2013.06.003
