Guidelines for the standardized collection of blood-based biomarkers in psychiatry: Steps for laboratory validity - a consensus of the Biomarkers Task Force from the WFSBP

Andreazza, Ana C; Laksono, Isabelle; Fernandes, Brisa S; Toben, Catherine; Lewczuk, Piotr; Riederer, Peter; Kennedy, Sidney H; Kapogiannis, Dimitrios; Thibaut, Florence; Gerlach, Manfred; Gallo, Carla; Kim, Yong-Ku; Grünblatt, Edna; Yatham, Lakshmi; Berk, Michael; Baune, Bernhard T

doi:10.5167/uzh-171525

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Andreazza, A. C., Laksono, I., Fernandes, B. S., Toben, C., Lewczuk, P., Riederer, P., Kennedy, S. H., Kapogiannis, D., Thibaut, F., Gerlach, M., Gallo, C., Kim, Y.-K., Grünblatt, E., Yatham, L., Berk, M., & Baune, B. T. (2019). Guidelines for the standardized collection of blood-based biomarkers in psychiatry: Steps for laboratory validity - a consensus of the Biomarkers Task Force from the WFSBP. World Journal of Biological Psychiatry, 20(5), 340–351. https://doi.org/10.1080/15622975.2019.1574024

Abstract

Recently, there has been a major shift in the field of psychiatry towards the exploration of complex relationships between blood-based biomarkers and the pathophysiology of psychiatric and neuropsychiatric disorders. However, issues with study reproducibility, validity and reliability have hindered progress towards the identification of clinically relevant biomarkers for psychiatry. The achievement of laboratory validity is a crucial first step for the posterior development of clinical validity. There is evidence that the variability