A Bufadienolide-Enriched Fraction of Bryophyllum pinnatum Inhibits Human Myometrial Contractility In Vitro

Santos, Stefanie; Haslinger, Christian; Klaic, Kristian; Faleschini, Maria T; Mennet, Mónica; Potterat, Olivier; von Mandach, Ursula; Hamburger, Matthias; Simões-Wüst, Ana Paula

doi:10.1055/a-0810-7704

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Santos, S., Haslinger, C., Klaic, K., Faleschini, M. T., Mennet, M., Potterat, O., von Mandach, U., Hamburger, M., & Simões-Wüst, A. P. (2019). A Bufadienolide-Enriched Fraction of Bryophyllum pinnatum Inhibits Human Myometrial Contractility In Vitro. Planta Medica, 85(5), 385–393. https://doi.org/10.1055/a-0810-7704

Abstract

Bryophyllum pinnatum has been used since the 1970s to prevent premature labour, first in anthroposophic hospitals and, more recently, also in the main Swiss perinatal centres. However, it is not known which compounds in B. pinnatum leaves contribute to the tocolytic effect. Here we studied the effects of a flavonoid-enriched fraction, the corresponding flavonoid aglycon mixture, a bufadienolide-enriched fraction, and B. pinnatum leaf press juice on human myometrial contractility in vitro. The strength (area under the curve and amplitu