Publication: Association between prefrontal glutamine levels and neuroticism determined using proton magnetic resonance spectroscopy
Association between prefrontal glutamine levels and neuroticism determined using proton magnetic resonance spectroscopy
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Hasler, G., Buchmann, A., Haynes, M., Müller, S. T., Ghisleni, C., Brechbühl, S., & Tuura, R. (2019). Association between prefrontal glutamine levels and neuroticism determined using proton magnetic resonance spectroscopy. Translational Psychiatry, 9, 170. https://doi.org/10.1038/s41398-019-0500-z
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There is growing evidence for GABA and glutamate-glutamine dysfunction in the pathogenesis of mood and anxiety disorders. It is important to study this pathology in the early phases of the illness in order to develop new approaches to secondary prevention. New magnetic resonance spectroscopy (MRS) measures allow determining glutamine, the principal metabolite of synaptic glutamate that is directly related to glutamate levels in the synaptic cleft, as well as glutamate and GABA. In contrast to previous investigations, this study used c
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Hasler, G., Buchmann, A., Haynes, M., Müller, S. T., Ghisleni, C., Brechbühl, S., & Tuura, R. (2019). Association between prefrontal glutamine levels and neuroticism determined using proton magnetic resonance spectroscopy. Translational Psychiatry, 9, 170. https://doi.org/10.1038/s41398-019-0500-z