Publication: Pilot Sub-Study of the Effect of Hepatitis C Cure by Glecaprevir/Pibrentasvir on the Gut Microbiome of Patients with Chronic Hepatitis C Genotypes 1 to 6 in the Mythen Study
Pilot Sub-Study of the Effect of Hepatitis C Cure by Glecaprevir/Pibrentasvir on the Gut Microbiome of Patients with Chronic Hepatitis C Genotypes 1 to 6 in the Mythen Study
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Yilmaz, B., Ruckstuhl, L., Müllhaupt, B., Magenta, L., Kuster, M. H., Clerc, O., Torgler, R., & Semmo, N. (2021). Pilot Sub-Study of the Effect of Hepatitis C Cure by Glecaprevir/Pibrentasvir on the Gut Microbiome of Patients with Chronic Hepatitis C Genotypes 1 to 6 in the Mythen Study. Pharmaceuticals, 14, 931. https://doi.org/10.3390/ph14090931
Abstract
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Abstract
In this small pilot sub-study, longitudinal gut microbiota composition changes, after successful treatment of hepatitis C virus (HCV) with the co-formulated glecaprevir/pibrentasvir (GLE/PIB), were analyzed before treatment (baseline) and 12 weeks post-treatment. Participating patients provided a fresh stool sample the week before their study visit, from which microbial DNA was extracted and sequenced for the 16S rRNA region in an Illumina MiSeq2 platform. Microbial and statistical analyses were conducted to determine the alpha-divers
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- Yilmaz, Bahtiyar
- Ruckstuhl, Lisa
- Müllhaupt, Beat
- Magenta, Lorenzo
- Kuster, Melanie Harrer
- Clerc, Olivier
- Torgler, Ralph
- Semmo, Nasser
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Yilmaz, B., Ruckstuhl, L., Müllhaupt, B., Magenta, L., Kuster, M. H., Clerc, O., Torgler, R., & Semmo, N. (2021). Pilot Sub-Study of the Effect of Hepatitis C Cure by Glecaprevir/Pibrentasvir on the Gut Microbiome of Patients with Chronic Hepatitis C Genotypes 1 to 6 in the Mythen Study. Pharmaceuticals, 14, 931. https://doi.org/10.3390/ph14090931
