Quantitative H2[(15)O]-PET in pediatric moyamoya disease: evaluating perfusion before and after cerebral revascularization

Kuhn, Felix P; Warnock, Geoff; Schweingruber, Thomas; Sommerauer, Michael; Buck, Alfred; Khan, Nadia

doi:10.1016/j.jstrokecerebrovasdis.2014.12.017

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Kuhn, F. P., Warnock, G., Schweingruber, T., Sommerauer, M., Buck, A., & Khan, N. (2015). Quantitative H2[(15)O]-PET in pediatric moyamoya disease: evaluating perfusion before and after cerebral revascularization. Journal of Stroke and Cerebrovascular Diseases, 24, 965–971. https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.12.017

Abstract

BACKGROUND Moyamoya disease (MMD) is an idiopathic intracranial angiopathy with a progressive spontaneous occlusion of the circle of Willis resulting in repeated ischemia if not diagnosed and treated early, especially in children. Prevention of stroke is achieved by revascularization of the affected cerebral regions. Functional imaging techniques such as H2[(15)O]-Positron emission tomography (PET) allow quantification of cerebral perfusion/blood flow (CBF) and in particular cerebrovascular response after acetazolamide (AZA) challeng