Publication: UMOD Genotype and Determinants of Urinary Uromodulin in African Populations
UMOD Genotype and Determinants of Urinary Uromodulin in African Populations
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Strauss-Kruger, M., Olinger, E., Hofmann, P., Wilson, I. J., Mels, C., Kruger, R., Gafane-Matemane, L. F., Sayer, J. A., Ricci, C., Schutte, A. E., & Devuyst, O. (2024). UMOD Genotype and Determinants of Urinary Uromodulin in African Populations. Kidney International Reports, 9, 3477–3489. https://doi.org/10.1016/j.ekir.2024.09.015
Abstract
Abstract
Abstract
INTRODUCTION
Single-nucleotide polymorphisms (SNPs) in the UMOD -PDILT genetic locus are associated with chronic kidney disease (CKD) in European populations, through their effect on urinary uromodulin (uUMOD) levels. The genetic and nongenetic factors associated with uUMOD in African populations remain unknown.
METHODS
Clinical parameters, 3 selected UMOD-PDILT SNPs and uUMOD levels were obtained in 1202 young Black and White adults from the African-PREDICT study and 1943 middle aged Black adults from the PURE-NWP-SA study, 2 cros
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- Strauss-Kruger, Michél
- Olinger, Eric
- Hofmann, Patrick
- Wilson, Ian J
- Mels, Carina
- Kruger, Ruan
- Gafane-Matemane, Lebo F
- Sayer, John A
- Ricci, Cristian
- Schutte, Aletta E
- Devuyst, Olivier
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Strauss-Kruger, M., Olinger, E., Hofmann, P., Wilson, I. J., Mels, C., Kruger, R., Gafane-Matemane, L. F., Sayer, J. A., Ricci, C., Schutte, A. E., & Devuyst, O. (2024). UMOD Genotype and Determinants of Urinary Uromodulin in African Populations. Kidney International Reports, 9, 3477–3489. https://doi.org/10.1016/j.ekir.2024.09.015
