Publication: Loss of tolerance precedes triggering and lifelong persistence of pathogenic type I interferon autoantibodies
Loss of tolerance precedes triggering and lifelong persistence of pathogenic type I interferon autoantibodies
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Fernbach, S., Mair, N. K., Abela, I. A., Groen, K., Kuratli, R., Lork, M., Thorball, C. W., Bernasconi, E., Filippidis, P., Leuzinger, K., Notter, J., Rauch, A., Hirsch, H. H., Huber, M., Günthard, H. F., Fellay, J., Kouyos, R. D., Hale, B. G., & Swiss HIV Cohort Study. (2024). Loss of tolerance precedes triggering and lifelong persistence of pathogenic type I interferon autoantibodies. Journal of Experimental Medicine, 221(9), e20240365. https://doi.org/10.1084/jem.20240365
Abstract
Abstract
Abstract
Autoantibodies neutralizing type I interferons (IFN-Is) can underlie infection severity. Here, we trace the development of these autoantibodies at high-resolution using longitudinal samples from 1,876 well-treated individuals living with HIV over a 35-year period. Similar to general populations, ∼1.9% of individuals acquired anti-IFN-I autoantibodies as they aged (median onset ∼63 years). Once detected, anti-IFN-I autoantibodies persisted lifelong, and titers increased over decades. Individuals developed distinct neutralizing and non-
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Creators (Authors)
- Fernbach, Sonja
- Mair, Nina K
- Abela, Irene A
- Groen, Kevin
- Kuratli, Roger
- Lork, Marie
- Thorball, Christian W
- Bernasconi, Enos
- Filippidis, Paraskevas
- Leuzinger, Karoline
- Notter, Julia
- Rauch, Andri
- Hirsch, Hans H
- Günthard, Huldrych F
- Fellay, Jacques
- Kouyos, Roger D
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Citations
Fernbach, S., Mair, N. K., Abela, I. A., Groen, K., Kuratli, R., Lork, M., Thorball, C. W., Bernasconi, E., Filippidis, P., Leuzinger, K., Notter, J., Rauch, A., Hirsch, H. H., Huber, M., Günthard, H. F., Fellay, J., Kouyos, R. D., Hale, B. G., & Swiss HIV Cohort Study. (2024). Loss of tolerance precedes triggering and lifelong persistence of pathogenic type I interferon autoantibodies. Journal of Experimental Medicine, 221(9), e20240365. https://doi.org/10.1084/jem.20240365
