Myocardial transcription of inflammatory and remodeling markers in cats with hypertrophic cardiomyopathy and systemic diseases associated with an inflammatory phenotype

Fonfara, Sonja; Kitz, Sarah; Monteith, Gabrielle; Hahn, Shelley; Kipar, Anja

doi:10.1016/j.rvsc.2021.03.027

Citations

Citation copied

Fonfara, S., Kitz, S., Monteith, G., Hahn, S., & Kipar, A. (2021). Myocardial transcription of inflammatory and remodeling markers in cats with hypertrophic cardiomyopathy and systemic diseases associated with an inflammatory phenotype. Research in Veterinary Science, 136, 484–494. https://doi.org/10.1016/j.rvsc.2021.03.027

Abstract

Feline hypertrophic cardiomyopathy (HCM) is characterized by macrophage-driven myocardial remodeling processes in a pro-inflammatory environment. To further investigate the mechanisms behind these processes, the myocardial transcription of cytokines and remodeling enzymes was comparatively assessed in cats with HCM and cats without cardiac diseases. Sixty-seven cats were included, 17 cats with HCM (including 5 with atrial thrombus; AT), and 50 cats without cardiac diseases. The latter comprised 10 control cats (no cardiac or relevant