Publication: Degeneration of the cerebellar granule cell layer in transgenic mice expressing genes of human foamy virus.
Degeneration of the cerebellar granule cell layer in transgenic mice expressing genes of human foamy virus.
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Lampe, J. B., Marino, S., Rethwilm, A., & Aguzzi, A. (1998). Degeneration of the cerebellar granule cell layer in transgenic mice expressing genes of human foamy virus. Neuropathology and Applied Neurobiology, 24(1), 36–43. https://doi.org/10.1046/j.1365-2990.1998.00086.x
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Transgenic mice expressing various combinations of structural and regulatory genes of human foamy virus (HFV) develop a neurodegenerative syndrome. delta gpe transgenic mice (which express the auxiliary bel-1 and bet genes along with truncated forms of gag, pol, and env) develop a severe neurological syndrome consisting mainly of spastic tetraparesis and blindness, and show neuronal loss in the hippocampus and cerebral cortex. In addition, mice in two of eight delta gpe lines developed an ataxic gait. Here we studied the phenotype of
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- Marino, S
- Rethwilm, A
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Lampe, J. B., Marino, S., Rethwilm, A., & Aguzzi, A. (1998). Degeneration of the cerebellar granule cell layer in transgenic mice expressing genes of human foamy virus. Neuropathology and Applied Neurobiology, 24(1), 36–43. https://doi.org/10.1046/j.1365-2990.1998.00086.x