Publication: The Urinary Excretion of Uromodulin is Regulated by the Potassium Channel ROMK
The Urinary Excretion of Uromodulin is Regulated by the Potassium Channel ROMK
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Schiano, G., Glaudemans, B., Olinger, E., Goelz, N., Müller, M., Loffing-Cueni, D., Deschenes, G., Loffing, J., & Devuyst, O. (2019). The Urinary Excretion of Uromodulin is Regulated by the Potassium Channel ROMK. Scientific Reports, 9, 19517. https://doi.org/10.1038/s41598-019-55771-x
Abstract
Abstract
Abstract
Uromodulin, the most abundant protein in normal urine, is produced by cells lining the thick ascending limb (TAL) of the loop of Henle. Uromodulin regulates the activity of the potassium channel ROMK in TAL cells. Common variants in KCNJ1, the gene encoding ROMK, are associated with urinary levels of uromodulin in population studies. Here, we investigated the functional link between ROMK and uromodulin in Kcnj1 knock-out mouse models, in primary cultures of mouse TAL (mTAL) cells, and in patients with Bartter syndrome due to KCNJ1 mut
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- Schiano, Guglielmo
- Glaudemans, Bob
- Olinger, Eric
- Goelz, Nadine
- Müller, Michael
- Loffing-Cueni, Dominique
- Deschenes, Georges
- Loffing, Johannes
- Devuyst, Olivier
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Schiano, G., Glaudemans, B., Olinger, E., Goelz, N., Müller, M., Loffing-Cueni, D., Deschenes, G., Loffing, J., & Devuyst, O. (2019). The Urinary Excretion of Uromodulin is Regulated by the Potassium Channel ROMK. Scientific Reports, 9, 19517. https://doi.org/10.1038/s41598-019-55771-x
