Publication: Targeting Oncolytic Adenoviruses to Cancer Cells Using a Designed Ankyrin Repeat Protein Lipocalin-2 Fusion Protein
Targeting Oncolytic Adenoviruses to Cancer Cells Using a Designed Ankyrin Repeat Protein Lipocalin-2 Fusion Protein
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Schellhorn, S., Brücher, D., Wolff, N. A., Schröer, K., Sallard, E., Mese, K., Zhang, W., Ehrke-Schulz, E., Thévenod, F., Plückthun, A., & Ehrhardt, A. (2023). Targeting Oncolytic Adenoviruses to Cancer Cells Using a Designed Ankyrin Repeat Protein Lipocalin-2 Fusion Protein. Human Gene Therapy, 34(5–6), 203–216. https://doi.org/10.1089/hum.2022.215
Abstract
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Oncolytic viruses are a promising technology to attack cancer cells and to recruit immune cells to the tumor site. Since the Lipocalin-2 receptor (LCN2R) is expressed on most cancer cells, we used its ligand LCN2 to target oncolytic adenoviruses (Ads) to cancer cells. Therefore, we fused a Designed Ankyrin Repeat Protein (DARPin) adapter binding the knob of Ad type 5 (knob5) to LCN2 to retarget the virus toward LCN2R with the aim of analyzing the basic characteristics of this novel targeting approach. The adapter was tested in vitro w
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- Schellhorn, Sebastian
- Brücher, Dominik
- Wolff, Natascha A
- Schröer, Katrin
- Sallard, Erwan
- Mese, Kemal
- Zhang, Wenli
- Ehrke-Schulz, Eric
- Thévenod, Frank
- Ehrhardt, Anja
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Schellhorn, S., Brücher, D., Wolff, N. A., Schröer, K., Sallard, E., Mese, K., Zhang, W., Ehrke-Schulz, E., Thévenod, F., Plückthun, A., & Ehrhardt, A. (2023). Targeting Oncolytic Adenoviruses to Cancer Cells Using a Designed Ankyrin Repeat Protein Lipocalin-2 Fusion Protein. Human Gene Therapy, 34(5–6), 203–216. https://doi.org/10.1089/hum.2022.215
