Publication: Real-world trough concentrations and effectiveness of long-acting cabotegravir and rilpivirine: a multicenter prospective observational study in Switzerland
Real-world trough concentrations and effectiveness of long-acting cabotegravir and rilpivirine: a multicenter prospective observational study in Switzerland
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Thoueille, P., Saldanha, S. A., Schaller, F., Choong, E., Munting, A., Cavassini, M., Braun, D., Günthard, H. F., Kusejko, K., Surial, B., Furrer, H., Rauch, A., Rougemont, M., Ustero, P., Calmy, A., Stöckle, M., Marzolini, C., Di Benedetto, C., Bernasconi, E., … Swiss HIV Cohort Study. (2024). Real-world trough concentrations and effectiveness of long-acting cabotegravir and rilpivirine: a multicenter prospective observational study in Switzerland. The Lancet Regional Health. Europe, 36, 100793. https://doi.org/10.1016/j.lanepe.2023.100793
Abstract
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BACKGROUND: The efficacy and tolerability of long-acting cabotegravir and rilpivirine were demonstrated in Phase III trials. However, low concentrations combined with other risk factors have been associated with an increased risk of virologic failure. This study aims to verify whether drug concentrations measured in a real-world setting are consistent with those previously reported.
METHODS: SHCS-879 is a nationwide observational study within the Swiss HIV Cohort Study for the monitoring of people with HIV (PWH) on long-acting cabote
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Creators (Authors)
- Thoueille, Paul
- Saldanha, Susana Alves
- Schaller, Fabian
- Choong, Eva
- Munting, Aline
- Cavassini, Matthias
- Braun, Dominique
- Günthard, Huldrych F
- Kusejko, Katharina
- Surial, Bernard
- Furrer, Hansjakob
- Rauch, Andri
- Rougemont, Mathieu
- Ustero, Pilar
- Calmy, Alexandra
- Stöckle, Marcel
- Marzolini, Catia
- Di Benedetto, Caroline
- Bernasconi, Enos
- Schmid, Patrick
- Piso, Rein Jan
- Andre, Pascal
- Girardin, François R
- Guidi, Monia
- Buclin, Thierry
- Decosterd, Laurent A
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Thoueille, P., Saldanha, S. A., Schaller, F., Choong, E., Munting, A., Cavassini, M., Braun, D., Günthard, H. F., Kusejko, K., Surial, B., Furrer, H., Rauch, A., Rougemont, M., Ustero, P., Calmy, A., Stöckle, M., Marzolini, C., Di Benedetto, C., Bernasconi, E., … Swiss HIV Cohort Study. (2024). Real-world trough concentrations and effectiveness of long-acting cabotegravir and rilpivirine: a multicenter prospective observational study in Switzerland. The Lancet Regional Health. Europe, 36, 100793. https://doi.org/10.1016/j.lanepe.2023.100793
