Publication: Whole Blood as a Sample Matrix in Homogeneous Time-Resolved Assay—Förster Resonance Energy Transfer-Based Antibody Detection
Whole Blood as a Sample Matrix in Homogeneous Time-Resolved Assay—Förster Resonance Energy Transfer-Based Antibody Detection
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Lintala, A., Vapalahti, O., Nousiainen, A., Kantele, A., & Hepojoki, J. (2024). Whole Blood as a Sample Matrix in Homogeneous Time-Resolved Assay—Förster Resonance Energy Transfer-Based Antibody Detection. Diagnostics, 14(7), 720. https://doi.org/10.3390/diagnostics14070720
Abstract
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Abstract
The protein-L-utilizing Förster resonance energy transfer (LFRET) assay enables mix-and-read antibody detection, as demonstrated for sera from patients with, e.g., severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Zika virus, and orthohantavirus infections. In this study, we compared paired serum and whole blood (WB) samples of COVID-19 patients and SARS-CoV-2 vaccine recipients. We found that LFRET also detects specific antibodies in WB samples. In 44 serum–WB pairs from patients with laboratory-confirmed COVID-19, LFRET
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- Lintala, Annika
- Vapalahti, Olli
- Nousiainen, Arttu
- Kantele, Anu
- Hepojoki, Jussi
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Finnish Medical Association
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Sigrid Jusélius Foundation
University of Helsinki
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Lintala, A., Vapalahti, O., Nousiainen, A., Kantele, A., & Hepojoki, J. (2024). Whole Blood as a Sample Matrix in Homogeneous Time-Resolved Assay—Förster Resonance Energy Transfer-Based Antibody Detection. Diagnostics, 14(7), 720. https://doi.org/10.3390/diagnostics14070720
