Cerebrospinal fluid pressure dynamics across the intra- and postoperative setting: Retrospective study of a spine surgery cohort

Kheram, Najmeh; Boraschi, Andrea; Aguirre, José; Farshad, Mazda; Pfender, Nikolai; Curt, Armin; Schubert, Martin; Kurtcuoglu, Vartan; Zipser, Carl M

doi:10.5167/uzh-262912

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Kheram, N., Boraschi, A., Aguirre, J., Farshad, M., Pfender, N., Curt, A., Schubert, M., Kurtcuoglu, V., & Zipser, C. M. (2024). Cerebrospinal fluid pressure dynamics across the intra- and postoperative setting: Retrospective study of a spine surgery cohort. Journal of Clinical Neuroscience, 128, 110803. https://doi.org/10.1016/j.jocn.2024.110803

Abstract

Timely and sufficient decompression are critical objectives in degenerative cervical myelopathy (DCM) and spinal cord injury (SCI). We previously investigated intraoperative cerebrospinal fluid pressure (CSFP) for determining surgical outcomes. However, confounding factors during the intra- and postoperative setting need consideration. These are related to type of respiration (i.e., artificial vs. natural) and anesthesia, which affect CSFP dynamics through the interaction between the cardiorespiratory system and the CSF compartment. T