Publication: Spatiotemporal Landscape of Kidney Tubular Responses to Glomerular Proteinuria
Spatiotemporal Landscape of Kidney Tubular Responses to Glomerular Proteinuria
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Faivre, A., Bugarski, M., Rinaldi, A., Sakhi, I. B., Verissimo, T., Legouis, D., Correia, S., Kaminska, M., Dalga, D., Malpetti, D., Cippa, P. E., de Seigneux, S., & Hall, A. M. (2024). Spatiotemporal Landscape of Kidney Tubular Responses to Glomerular Proteinuria. Journal of the American Society of Nephrology (JASN), 35(7), 854–869. https://doi.org/10.1681/ASN.0000000000000357
Abstract
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BACKGROUND
Large increases in glomerular protein filtration induce major changes in body homeostasis and increase risk of kidney functional decline and cardiovascular disease. We investigated how elevated protein exposure modifies the landscape of tubular function along the entire nephron, to understand the cellular changes that mediate these important clinical phenomena.
METHODS
We conducted single nuclei RNA sequencing, functional intravital imaging, and antibody staining to spatially map transport processes along the mouse kidne
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Faivre, A., Bugarski, M., Rinaldi, A., Sakhi, I. B., Verissimo, T., Legouis, D., Correia, S., Kaminska, M., Dalga, D., Malpetti, D., Cippa, P. E., de Seigneux, S., & Hall, A. M. (2024). Spatiotemporal Landscape of Kidney Tubular Responses to Glomerular Proteinuria. Journal of the American Society of Nephrology (JASN), 35(7), 854–869. https://doi.org/10.1681/ASN.0000000000000357
