Publication: Tissue-engineered dermo-epidermal skin grafts prevascularized with adipose-derived cells
Tissue-engineered dermo-epidermal skin grafts prevascularized with adipose-derived cells
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Klar, A. S., Güven, S., Biedermann, T., Luginbühl, J., Böttcher-Haberzeth, S., Meuli-Simmen, C., Meuli, M., Martin, I., Scherberich, A., & Reichmann, E. (2014). Tissue-engineered dermo-epidermal skin grafts prevascularized with adipose-derived cells. Biomaterials, 35, 5065–5078. https://doi.org/10.1016/j.biomaterials.2014.02.049
Abstract
Abstract
Abstract
The major problem in skin grafting is that tissue-engineered skin grafts after their transplantation are initially entirely dependent on diffusion. Since this process is slow and inefficient, nutrients, growth factors, and oxygen will insufficiently be supplied and the regenerating graft will undergo a physiological crisis, resulting in scar-like dermal structures and shrinkage. The tissue-engineering of a vascular network in human dermo-epidermal skin substitutes (DESS) is a promising approach to overcome this limitation. Here we rep
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Creators (Authors)
- Klar, Agnieszka S
- Güven, Sinan
- Biedermann, Thomas
- Luginbühl, Joachim
- Böttcher-Haberzeth, Sophie
- Meuli, Martin
- Martin, Ivan
- Scherberich, Arnaud
- Reichmann, Ernst
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Citations
Klar, A. S., Güven, S., Biedermann, T., Luginbühl, J., Böttcher-Haberzeth, S., Meuli-Simmen, C., Meuli, M., Martin, I., Scherberich, A., & Reichmann, E. (2014). Tissue-engineered dermo-epidermal skin grafts prevascularized with adipose-derived cells. Biomaterials, 35, 5065–5078. https://doi.org/10.1016/j.biomaterials.2014.02.049
