Publication: Evaluation of the radiolabeled boronic acid-based FAP inhibitor MIP-1232 for atherosclerotic plaque imaging
Evaluation of the radiolabeled boronic acid-based FAP inhibitor MIP-1232 for atherosclerotic plaque imaging
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Meletta, R., Müller Herde, A., Chiotellis, A., Isa, M., Rancic, Z., Borel, N., Ametamey, S. M., Krämer, S. D., & Schibli, R. (2015). Evaluation of the radiolabeled boronic acid-based FAP inhibitor MIP-1232 for atherosclerotic plaque imaging. Molecules, 20(2), 2081–2099. https://doi.org/10.3390/molecules20022081
Abstract
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Abstract
Research towards the non-invasive imaging of atherosclerotic plaques is of high clinical priority as early recognition of vulnerable plaques may reduce the incidence of cardiovascular events. The fibroblast activation protein alpha (FAP) was recently proposed as inflammation-induced protease involved in the process of plaque vulnerability. In this study, FAP mRNA and protein levels were investigated by quantitative polymerase chain reaction and immunohistochemistry, respectively, in human endarterectomized carotid plaques. A published
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Creators (Authors)
- Meletta, Romana
- Müller Herde, Adrienne
- Chiotellis, Aristeidis
- Isa, Malsor
- Rancic, Zoran
- Borel, Nicole
- Ametamey, Simon M
- Krämer, Stefanie D
- Schibli, Roger
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Citations
Meletta, R., Müller Herde, A., Chiotellis, A., Isa, M., Rancic, Z., Borel, N., Ametamey, S. M., Krämer, S. D., & Schibli, R. (2015). Evaluation of the radiolabeled boronic acid-based FAP inhibitor MIP-1232 for atherosclerotic plaque imaging. Molecules, 20(2), 2081–2099. https://doi.org/10.3390/molecules20022081
