Publication: The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress
The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress
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Han, Z., Andrs, M., Madhavan, B. K., Kaymak, S., Sulaj, A., Kender, Z., Kopf, S., Kihm, L., Pepperkok, R., Janscak, P., Nawroth, P., & Kumar, V. (2023). The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress. Nucleic Acids Research, 51(5), 2298–2318. https://doi.org/10.1093/nar/gkad085
Abstract
Abstract
Abstract
An elevated frequency of DNA replication defects is associated with diabetes and cancer. However, data linking these nuclear perturbations to the onset or progression of organ complications remained unexplored. Here, we report that RAGE (Receptor for Advanced Glycated Endproducts), previously believed to be an extracellular receptor, upon metabolic stress localizes to the damaged forks. There it interacts and stabilizes the minichromosome-maintenance (Mcm2-7) complex. Accordingly, RAGE deficiency leads to slowed fork progression, prem
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Creators (Authors)
- Han, Zhe
- Andrs, Martin
- Madhavan, Bindhu K
- Kaymak, Serap
- Sulaj, Alba
- Kender, Zoltan
- Kopf, Stefan
- Kihm, Lars
- Pepperkok, Rainer
- Janscak, Pavel
- Nawroth, Peter
- Kumar, Varun
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Citations
Han, Z., Andrs, M., Madhavan, B. K., Kaymak, S., Sulaj, A., Kender, Z., Kopf, S., Kihm, L., Pepperkok, R., Janscak, P., Nawroth, P., & Kumar, V. (2023). The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress. Nucleic Acids Research, 51(5), 2298–2318. https://doi.org/10.1093/nar/gkad085
