Publication: Synthesis, Characterization and Biological Evaluation of New Ru(II) Polypyridyl Photosensitizers for Photodynamic Therapy
Synthesis, Characterization and Biological Evaluation of New Ru(II) Polypyridyl Photosensitizers for Photodynamic Therapy
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Frei, A., Rubbiani, R., Tubafard, S., Blacque, O., Anstätt, P., Felgenträger, A., Maisch, T., Spiccia, L., & Gasser, G. (2014). Synthesis, Characterization and Biological Evaluation of New Ru(II) Polypyridyl Photosensitizers for Photodynamic Therapy. Journal of Medicinal Chemistry, 57, 7280–7292. https://doi.org/10.1021/jm500566f
Abstract
Abstract
Abstract
Two Ru(II) polypyridyl complexes, Ru(DIP)2(bdt) (1) and Ru(dqpCO2Me)(ptpy) (2) (DIP = 4,7-diphenyl-1,10-phenanthroline, bdt = 1,2-benzenedithiolate, dqpCO2Me = 4-methylcarboxy-2,6-di(quinolin-8-yl)pyridine), ptpy = 4'-phenyl-2,2':6',2″-terpyridine) have been investigated as photosensitizers (PSs) for photodynamic therapy (PDT). In our experimental settings, the phototoxicity and phototoxic index (PI) of 2 (IC50(light): 25.3 μM, 420 nm, 6.95 J/cm(2); PI >4) and particularly of 1 (IC50(light): 0.62 μM, 420 nm, 6.95 J/cm(2); PI: 80
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Creators (Authors)
- Frei, Angelo
- Rubbiani, Riccardo
- Tubafard, Solmaz
- Blacque, Olivier
- Anstätt, Philipp
- Felgenträger, Ariane
- Maisch, Tim
- Spiccia, Leone
- Gasser, Gilles
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Citations
Frei, A., Rubbiani, R., Tubafard, S., Blacque, O., Anstätt, P., Felgenträger, A., Maisch, T., Spiccia, L., & Gasser, G. (2014). Synthesis, Characterization and Biological Evaluation of New Ru(II) Polypyridyl Photosensitizers for Photodynamic Therapy. Journal of Medicinal Chemistry, 57, 7280–7292. https://doi.org/10.1021/jm500566f
