Publication: Prazosin during threat discrimination boosts memory of the safe stimulus
Prazosin during threat discrimination boosts memory of the safe stimulus
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Homan, P., Lin, Q., Murrough, J. W., Soleimani, L., Bach, D. R., Clem, R. L., & Schiller, D. (2017). Prazosin during threat discrimination boosts memory of the safe stimulus. Learning & Memory, 24(11), 597–601. https://doi.org/10.1101/lm.045898.117
Abstract
Abstract
Abstract
The α-1 adrenoreceptor antagonist prazosin has shown promise in the treatment of post-traumatic stress disorder (PTSD) symptoms, but its mechanisms are not well understood. Here we administered prazosin or placebo prior to threat conditioning (day 1) and tested subsequent extinction (day 2) and reextinction (day 3) in healthy human participants. Prazosin did not affect threat conditioning but augmented stimulus discrimination during extinction and reextinction, via lower responding to the safe stimulus. These results suggest that praz
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Creators (Authors)
- Lin, Qi
- Murrough, James W
- Soleimani, Laili
- Bach, Dominik R
- Clem, Roger L
- Schiller, Daniela
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Homan, P., Lin, Q., Murrough, J. W., Soleimani, L., Bach, D. R., Clem, R. L., & Schiller, D. (2017). Prazosin during threat discrimination boosts memory of the safe stimulus. Learning & Memory, 24(11), 597–601. https://doi.org/10.1101/lm.045898.117
