Publication: Retinal degeneration modulates intracellular localization of CDC42 in photoreceptors
Retinal degeneration modulates intracellular localization of CDC42 in photoreceptors
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Citations
Heynen, S. R., Tanimoto, N., Joly, S., Seeliger, M. W., Samardzija, M., & Grimm, C. (2011). Retinal degeneration modulates intracellular localization of CDC42 in photoreceptors. Molecular Vision, 17, 2934–2946. http://www.molvis.org/molvis/v17/a317/
Abstract
Abstract
Abstract
Purpose: Rho GTPases such as RAS-related C3 botulinum substrate 1 (RAC1) and cell division cycle 42 homolog (S. cerevisiae; CDC42) have been linked to cellular processes including movement, development, and apoptosis. Recently, RAC1 has been shown to be a pro-apoptotic factor in the retina during light-induced photoreceptor degeneration. Here, we analyzed the role of CDC42 in the degenerating retina.
Methods: Photoreceptor degeneration was studied in a mouse model for autosomal dominant retinitis pigmentosa (VPP) with or without a ro
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Creators (Authors)
- Heynen, Severin R
- Tanimoto, Naoyuki
- Joly, Sandrine
- Seeliger, Mathias W
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Citations
Heynen, S. R., Tanimoto, N., Joly, S., Seeliger, M. W., Samardzija, M., & Grimm, C. (2011). Retinal degeneration modulates intracellular localization of CDC42 in photoreceptors. Molecular Vision, 17, 2934–2946. http://www.molvis.org/molvis/v17/a317/
