Publication: Differential ESR1 Promoter Methylation in the Peripheral Blood-Findings from the Women 40+ Healthy Aging Study
Differential ESR1 Promoter Methylation in the Peripheral Blood-Findings from the Women 40+ Healthy Aging Study
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Gardini, E. S., Chen, G. G., Fiacco, S., Mernone, L., Willi, J., Turecki, G., & Ehlert, U. (2020). Differential ESR1 Promoter Methylation in the Peripheral Blood-Findings from the Women 40+ Healthy Aging Study. International Journal of Molecular Sciences, 21(10), 3654. https://doi.org/10.3390/ijms21103654
Abstract
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Background Estrogen receptor α (ERα) contributes to maintaining biological processes preserving health during aging. DNA methylation changes of ERα gene (ESR1) were established as playing a direct role in the regulation of ERα levels. In this study, we hypothesized decreased DNA methylation of ESR1 associated with postmenopause, lower estradiol (E2) levels, and increased age among healthy middle-aged and older women. Methods We assessed DNA methylation of ESR1 promoter region from dried blood spots (DBSs) and E2 from saliva samples in
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Creators (Authors)
- Gardini, Elena S
- Chen, Gary G
- Fiacco, Serena
- Mernone, Laura
- Willi, Jasmine
- Turecki, Gustavo
- Ehlert, Ulrike
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Citations
Gardini, E. S., Chen, G. G., Fiacco, S., Mernone, L., Willi, J., Turecki, G., & Ehlert, U. (2020). Differential ESR1 Promoter Methylation in the Peripheral Blood-Findings from the Women 40+ Healthy Aging Study. International Journal of Molecular Sciences, 21(10), 3654. https://doi.org/10.3390/ijms21103654
