Publication: Somatostatin Containing δ-Cell Number Is Reduced in Type-2 Diabetes
Somatostatin Containing δ-Cell Number Is Reduced in Type-2 Diabetes
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Kothegala, L., Miranda, C., Singh, M., Krieger, J.-P., & Gandasi, N. R. (2023). Somatostatin Containing δ-Cell Number Is Reduced in Type-2 Diabetes. International Journal of Molecular Sciences, 24(4), 3449. https://doi.org/10.3390/ijms24043449
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Recent developments suggest that increased glucagon and decreased somatostatin secretion from the pancreas contribute to hyperglycaemia in type-2 diabetes (T2D) patients. There is a huge need to understand changes in glucagon and somatostatin secretion to develop potential anti-diabetic drugs. To further describe the role of somatostatin in the pathogenesis of T2D, reliable means to detect islet δ-cells and somatostatin secretion are necessary. In this study, we first tested currently available anti-somatostatin antibodies against a m
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- Kothegala, Lakshmi
- Miranda, Caroline
- Singh, Meetu
- Krieger, Jean-Philippe
- Gandasi, Nikhil R
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Kothegala, L., Miranda, C., Singh, M., Krieger, J.-P., & Gandasi, N. R. (2023). Somatostatin Containing δ-Cell Number Is Reduced in Type-2 Diabetes. International Journal of Molecular Sciences, 24(4), 3449. https://doi.org/10.3390/ijms24043449
