Publication: Long-term experimental evolution of HIV-1 reveals effects of environment and mutational history
Long-term experimental evolution of HIV-1 reveals effects of environment and mutational history
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Bons, E., Leemann, C., Metzner, K. J., & Regoes, R. R. (2020). Long-term experimental evolution of HIV-1 reveals effects of environment and mutational history. PLoS Biology, 18(12), e3001010. https://doi.org/10.1371/journal.pbio.3001010
Abstract
Abstract
Abstract
An often-returning question for not only HIV-1, but also other organisms, is how predictable evolutionary paths are. The environment, mutational history, and random processes can all impact the exact evolutionary paths, but to which extent these factors contribute to the evolutionary dynamics of a particular system is an open question. Especially in a virus like HIV-1, with a large mutation rate and large population sizes, evolution is expected to be highly predictable if the impact of environment and history is low, and evolution is
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- Bons, Eva
- Leemann, Christine
- Metzner, Karin J
- Regoes, Roland R
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Citations
Bons, E., Leemann, C., Metzner, K. J., & Regoes, R. R. (2020). Long-term experimental evolution of HIV-1 reveals effects of environment and mutational history. PLoS Biology, 18(12), e3001010. https://doi.org/10.1371/journal.pbio.3001010
