Publication: LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance
LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance
Date
Date
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Citations
Michalek, S., Goj, T., Plazzo, A. P., Marovca, B., Bornhauser, B., & Brunner, T. (2022). LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance. EMBO Reports, 23(9), e54195. https://doi.org/10.15252/embr.202154195
Abstract
Abstract
Abstract
Nuclear receptors are transcription factors with important functions in a variety of physiological and pathological processes. Targeting glucocorticoid receptor (GR) activity using glucocorticoids is a cornerstone in the treatment of patients with T cell acute lymphoblastic leukemia (T-ALL), and resistance to GC-induced cell death is associated with poor outcome and a high risk for relapse. Next to ligand-binding, heterodimerization with other transcription factors presents an important mechanism for the regulation of GR activity. Her
Additional indexing
Creators (Authors)
- Michalek, Svenja
- Goj, Thomas
- Plazzo, Anna Pia
- Marovca, Blerim
- Bornhauser, Beat
- Brunner, Thomas
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Citations
Michalek, S., Goj, T., Plazzo, A. P., Marovca, B., Bornhauser, B., & Brunner, T. (2022). LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance. EMBO Reports, 23(9), e54195. https://doi.org/10.15252/embr.202154195
