Publication: Antibody phage display assisted identification of junction plakoglobin as a potential biomarker for atherosclerosis
Antibody phage display assisted identification of junction plakoglobin as a potential biomarker for atherosclerosis
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Cooksley-Decasper, S., Reiser, H., Thommen, D. S., Biedermann, B., Neidhart, M., Gawinecka, J., Cathomas, G., Franzeck, F. C., Wyss, C., Klingenberg, R., Nanni, P., Roschitzki, B., Matter, C., Wolint, P., Emmert, M. Y., Husmann, M., Amann-Vesti, B., Maier, W., Gay, S., … Hof, D. (2012). Antibody phage display assisted identification of junction plakoglobin as a potential biomarker for atherosclerosis. PLoS ONE, 7(10), e47985. https://doi.org/10.1371/journal.pone.0047985
Abstract
Abstract
Abstract
To date, no plaque-derived blood biomarker is available to allow diagnosis, prognosis or monitoring of atherosclerotic vascular diseases. In this study, specimens of thrombendarterectomy material from carotid and iliac arteries were incubated in protein-free medium to obtain plaque and control secretomes for subsequent subtractive phage display. The selection of nine plaque secretome-specific antibodies and the analysis of their immunopurified antigens by mass spectrometry led to the identification of 22 proteins. One of them, junctio
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Creators (Authors)
- Cooksley-Decasper, Seraina
- Reiser, Hans
- Thommen, Daniela S
- Biedermann, Barbara
- Neidhart, Michel
- Gawinecka, Joanna
- Cathomas, Gieri
- Franzeck, Fabian C
- Wyss, Christophe
- Klingenberg, Roland
- Nanni, Paolo
- Roschitzki, Bernd
- Matter, Christian
- Wolint, Petra
- Emmert, Maximilian Y
- Husmann, Marc
- Amann-Vesti, Beatrice
- Maier, Wilibald
- Gay, Steffen
- Lüscher, Thomas F
- von Eckardstein, Arnold
- Hof, Danielle
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Citations
Cooksley-Decasper, S., Reiser, H., Thommen, D. S., Biedermann, B., Neidhart, M., Gawinecka, J., Cathomas, G., Franzeck, F. C., Wyss, C., Klingenberg, R., Nanni, P., Roschitzki, B., Matter, C., Wolint, P., Emmert, M. Y., Husmann, M., Amann-Vesti, B., Maier, W., Gay, S., … Hof, D. (2012). Antibody phage display assisted identification of junction plakoglobin as a potential biomarker for atherosclerosis. PLoS ONE, 7(10), e47985. https://doi.org/10.1371/journal.pone.0047985
