Publication: Intestinal vitamin D receptor modulates lipid metabolism, adipose tissue inflammation and liver steatosis in obese mice
Intestinal vitamin D receptor modulates lipid metabolism, adipose tissue inflammation and liver steatosis in obese mice
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Jahn, D., Dorbath, D., Schilling, A.-K., Gildein, L., Meier, C., Vuille-Dit-Bille, R. N., Schmitt, J., Kraus, D., Fleet, J. C., Hermanns, H. M., & Geier, A. (2019). Intestinal vitamin D receptor modulates lipid metabolism, adipose tissue inflammation and liver steatosis in obese mice. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1865(6), 1567–1578. https://doi.org/10.1016/j.bbadis.2019.03.007
Abstract
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OBJECTIVE
Hypovitaminosis D is common in the obese population and patients suffering from obesity-associated disorders such as type 2 diabetes and fatty liver disease, resulting in suggestions for vitamin D supplementation as a potential therapeutic option. However, the pathomechanistic contribution of the vitamin D-vitamin D receptor (VDR) axis to metabolic disorders is largely unknown.
METHODS
We analyzed the pathophysiological role of global and intestinal VDR signaling in diet-induced obesity (DIO) using global Vdr-/- mice and
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Creators (Authors)
- Jahn, Daniel
- Dorbath, Donata
- Schilling, Anne-Kristin
- Gildein, Lisa
- Meier, Chantal
- Vuille-Dit-Bille, Raphael N
- Schmitt, Johannes
- Kraus, Daniel
- Fleet, James C
- Hermanns, Heike M
- Geier, Andreas
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Jahn, D., Dorbath, D., Schilling, A.-K., Gildein, L., Meier, C., Vuille-Dit-Bille, R. N., Schmitt, J., Kraus, D., Fleet, J. C., Hermanns, H. M., & Geier, A. (2019). Intestinal vitamin D receptor modulates lipid metabolism, adipose tissue inflammation and liver steatosis in obese mice. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1865(6), 1567–1578. https://doi.org/10.1016/j.bbadis.2019.03.007