Publication: Astrocytes integrate and drive action potential firing in inhibitory subnetworks
Astrocytes integrate and drive action potential firing in inhibitory subnetworks
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Deemyad, T., Lüthi, J., & Spruston, N. (2018). Astrocytes integrate and drive action potential firing in inhibitory subnetworks. Nature Communications, 9(1), 4336. https://doi.org/10.1038/s41467-018-06338-3
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Many brain functions depend on the ability of neural networks to temporally integrate transient inputs to produce sustained discharges. This can occur through cell-autonomous mechanisms in individual neurons and through reverberating activity in recurrently connected neural networks. We report a third mechanism involving temporal integration of neural activity by a network of astrocytes. Previously, we showed that some types of interneurons can generate long-lasting trains of action potentials (barrage firing) following repeated depol
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Deemyad, T., Lüthi, J., & Spruston, N. (2018). Astrocytes integrate and drive action potential firing in inhibitory subnetworks. Nature Communications, 9(1), 4336. https://doi.org/10.1038/s41467-018-06338-3