Publication: Nogo-A regulates vascular network architecture in the postnatal brain
Nogo-A regulates vascular network architecture in the postnatal brain
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Wälchli, T., Ulmann-Schuler, A., Hintermüller, C., Meyer, E., Stampanoni, M., Carmeliet, P., Emmert, M. Y., Bozinov, O., Regli, L., Schwab, M. E., Vogel, J., & Hoerstrup, S. P. (2017). Nogo-A regulates vascular network architecture in the postnatal brain. Journal of Cerebral Blood Flow and Metabolism, 37(2), 614–631. https://doi.org/10.1177/0271678X16675182
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Recently, we discovered a new role for the well-known axonal growth inhibitory molecule Nogo-A as a negative regulator of angiogenesis in the developing central nervous system. However, how Nogo-A affected the three-dimensional (3D) central nervous system (CNS) vascular network architecture remained unknown. Here, using vascular corrosion casting, hierarchical, synchrotron radiation μCT-based network imaging and computer-aided network analysis, we found that genetic ablation of Nogo-A significantly increased the three-dimensional vasc
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Wälchli, T., Ulmann-Schuler, A., Hintermüller, C., Meyer, E., Stampanoni, M., Carmeliet, P., Emmert, M. Y., Bozinov, O., Regli, L., Schwab, M. E., Vogel, J., & Hoerstrup, S. P. (2017). Nogo-A regulates vascular network architecture in the postnatal brain. Journal of Cerebral Blood Flow and Metabolism, 37(2), 614–631. https://doi.org/10.1177/0271678X16675182