Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis

Krzywinska, Ewelina; Kantari-Mimoun, Chahrazade; Kerdiles, Yann; Sobecki, Michal; Isagawa, Takayuki; Gotthardt, Dagmar; Castells, Magali; Haubold, Johannes; Millien, Corinne; Viel, Thomas; Tavitian, Bertrand; Takeda, Norihiko; Fandrey, Joachim; Vivier, Eric; Sexl, Veronika; Stockmann, Christian

doi:10.5167/uzh-142158

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Krzywinska, E., Kantari-Mimoun, C., Kerdiles, Y., Sobecki, M., Isagawa, T., Gotthardt, D., Castells, M., Haubold, J., Millien, C., Viel, T., Tavitian, B., Takeda, N., Fandrey, J., Vivier, E., Sexl, V., & Stockmann, C. (2017). Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis. Nature Communications, 8, 1597. https://doi.org/10.1038/s41467-017-01599-w

Abstract

Productive angiogenesis, a prerequisite for tumour growth, depends on the balanced release of angiogenic and angiostatic factors by different cell types within hypoxic tumours. Natural killer (NK) cells kill cancer cells and infiltrate hypoxic tumour areas. Cellular adaptation to low oxygen is mediated by Hypoxia-inducible factors (HIFs). We found that deletion of HIF-1α in NK cells inhibited tumour growth despite impaired tumour cell killing. Tumours developing in these conditions were characterised by a high-density network of immat