Publication: Memory decline and its reversal in aging and neurodegeneration involve miR-183/96/182 biogenesis
Memory decline and its reversal in aging and neurodegeneration involve miR-183/96/182 biogenesis
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Jawaid, A., Woldemichael, B. T., Kremer, E. A., Laferriere, F., Gaur, N., Afroz, T., Polymenidou, M., & Mansuy, I. M. (2019). Memory decline and its reversal in aging and neurodegeneration involve miR-183/96/182 biogenesis. Molecular Neurobiology, 56(5), 3451–3462. https://doi.org/10.1007/s12035-018-1314-3
Abstract
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Abstract
Aging is characterized by progressive memory decline that can lead to dementia when associated with neurodegeneration. Here, we show in mice that aging-related memory decline involves defective biogenesis of microRNAs (miRNAs), in particular miR-183/96/182 cluster, resulting from increased protein phosphatase 1 (PP1) and altered receptor SMAD (R-SMAD) signaling. Correction of the defect by miR-183/96/182 overexpression in hippocampus or by environmental enrichment that normalizes PP1 activity restores memory in aged animals. Regulatio
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- Jawaid, Ali
- Woldemichael, Bisrat T
- Kremer, Eloïse A
- Laferriere, Florent
- Gaur, Niharika
- Afroz, Tariq
- Polymenidou, Magdalini
- Mansuy, Isabelle M
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Jawaid, A., Woldemichael, B. T., Kremer, E. A., Laferriere, F., Gaur, N., Afroz, T., Polymenidou, M., & Mansuy, I. M. (2019). Memory decline and its reversal in aging and neurodegeneration involve miR-183/96/182 biogenesis. Molecular Neurobiology, 56(5), 3451–3462. https://doi.org/10.1007/s12035-018-1314-3
