Publication: Identification of Carcinogenesis and Tumor Progression Processes in Pancreatic Ductal Adenocarcinoma Using High-Throughput Proteomics
Identification of Carcinogenesis and Tumor Progression Processes in Pancreatic Ductal Adenocarcinoma Using High-Throughput Proteomics
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Trilla-Fuertes, L., Gámez-Pozo, A., Lumbreras-Herrera, M. I., López-Vacas, R., Heredia-Soto, V., Ghanem, I., López-Camacho, E., Zapater-Moros, A., Miguel, M., Peña-Burgos, E. M., Palacios, E., De Uribe, M., Guerra, L., Dittmann, A., Mendiola, M., Fresno Vara, J. Á., & Feliu, J. (2022). Identification of Carcinogenesis and Tumor Progression Processes in Pancreatic Ductal Adenocarcinoma Using High-Throughput Proteomics. Cancers, 14(10), 2414. https://doi.org/10.3390/cancers14102414
Abstract
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Abstract
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with an overall 5-year survival rate of just 5%. A better understanding of the carcinogenesis processes and the mechanisms of the progression of PDAC is mandatory. Fifty-two PDAC patients treated with surgery and adjuvant therapy, with available primary tumors, normal tissue, preneoplastic lesions (PanIN), and/or lymph node metastases, were selected for the study. Proteins were extracted from small punches and analyzed by LC-MS/MS using data-independent acquisition. Prot
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- Trilla-Fuertes, Lucía
- Gámez-Pozo, Angelo
- Lumbreras-Herrera, María Isabel
- López-Vacas, Rocío
- Heredia-Soto, Victoria
- Ghanem, Ismael
- López-Camacho, Elena
- Zapater-Moros, Andrea
- Miguel, María
- Peña-Burgos, Eva M
- Palacios, Elena
- De Uribe, Marta
- Guerra, Laura
- Dittmann, Antje
- Mendiola, Marta
- Fresno Vara, Juan Ángel
- Feliu, Jaime
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Trilla-Fuertes, L., Gámez-Pozo, A., Lumbreras-Herrera, M. I., López-Vacas, R., Heredia-Soto, V., Ghanem, I., López-Camacho, E., Zapater-Moros, A., Miguel, M., Peña-Burgos, E. M., Palacios, E., De Uribe, M., Guerra, L., Dittmann, A., Mendiola, M., Fresno Vara, J. Á., & Feliu, J. (2022). Identification of Carcinogenesis and Tumor Progression Processes in Pancreatic Ductal Adenocarcinoma Using High-Throughput Proteomics. Cancers, 14(10), 2414. https://doi.org/10.3390/cancers14102414
