Publication: Contribution of IL-12R mediated feedback loop to Th1 cell differentiation
Contribution of IL-12R mediated feedback loop to Th1 cell differentiation
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Becskei, A., & Grusby, M. J. (2007). Contribution of IL-12R mediated feedback loop to Th1 cell differentiation. FEBS Letters, 581, 5199–5206. https://doi.org/10.1016/j.febslet.2007.10.007
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Abstract
T helper 1 (Th1) cell fate is induced by overlapping signaling pathways, whose kinetic principles and regulatory motifs are largely unknown. We identified a simple positive feedback loop in the STAT4 signaling pathway, whereby activation by IL-12 leads to the increased expression in IL-12 receptor. A computational analysis shows that this feedback loop synergizes with the one mediated by the IFN-gamma secreted by differentiating cells, when the induction of Th1 cell fate is weak. Positive feedback loops are often utilized to enhance p
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- Becskei, A
- Grusby, M J
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Citations
Becskei, A., & Grusby, M. J. (2007). Contribution of IL-12R mediated feedback loop to Th1 cell differentiation. FEBS Letters, 581, 5199–5206. https://doi.org/10.1016/j.febslet.2007.10.007
