Publication: Astrocyte- and Microglia-Specific Mitochondrial DNA Deletions Levels in Sporadic Alzheimer's Disease
Astrocyte- and Microglia-Specific Mitochondrial DNA Deletions Levels in Sporadic Alzheimer's Disease
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Strobel, S., Grünblatt, E., Heinsen, H., Riederer, P., Espach, T., Meder, M., & Monoranu, C.-M. (2019). Astrocyte- and Microglia-Specific Mitochondrial DNA Deletions Levels in Sporadic Alzheimer’s Disease. Journal of Alzheimer’s Disease, 67(1), 149–157. https://doi.org/10.3233/JAD-180661
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Oxidative stress is implicated in the pathogenesis of neurodegenerative diseases, including sporadic Alzheimer's disease (AD). Mitochondrial DNA (mtDNA) deletions are markers of oxidative damage with an age-dependent accumulation. In a previous study, we analyzed mtDNA levels in diverse neuronal cell types in order to unravel the impact of oxidative stress in brains of AD patients. The aim of this study was to identify possible correlations between mtDNA deletion levels of selected astrocytes and microglia from three brain regions wit
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Creators (Authors)
- Strobel, Sabrina
- Grünblatt, Edna
- Heinsen, Helmut
- Riederer, Peter
- Espach, Thomas
- Meder, Michael
- Monoranu, Camelia-Maria
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Citations
Strobel, S., Grünblatt, E., Heinsen, H., Riederer, P., Espach, T., Meder, M., & Monoranu, C.-M. (2019). Astrocyte- and Microglia-Specific Mitochondrial DNA Deletions Levels in Sporadic Alzheimer’s Disease. Journal of Alzheimer’s Disease, 67(1), 149–157. https://doi.org/10.3233/JAD-180661
