Publication: CD8 + T-cells restrict the development of peritoneal metastasis and support the efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC)
CD8 + T-cells restrict the development of peritoneal metastasis and support the efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC)
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Roth, L., Huynh-Russo, L., Heeb, L., Ulugöl, S., Freire Dos Santos, R., Breuer, E., Ungethüm, U., Haberecker, M., Pauli, C., Koelzer, V., Lehmann, K., & Gupta, A. (2024). CD8 + T-cells restrict the development of peritoneal metastasis and support the efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC). Scientific Reports, 14(1), 22324. https://doi.org/10.1038/s41598-024-72826-w
Abstract
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Abstract
Multimodal therapy for peritoneal metastasis (PM) including cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provides long-term survival in highly selected colorectal cancer patients. Mechanisms behind HIPEC are unknown and may include induction of adaptive immunity. We therefore analyzed human PM samples and explored the impact of HIPEC in experimental models. Human samples from colorectal primary tumors (n = 19) and PM lesions (n = 37) were examined for the presence of CD8 + T-cells and their associa
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Creators (Authors)
- Roth, Lilian
- Huynh-Russo, Linda
- Heeb, Laura
- Ulugöl, Sima
- Freire Dos Santos, Rafael
- Breuer, Eva
- Ungethüm, Udo
- Haberecker, Martina
- Pauli, Chantal
- Lehmann, Kuno
- Gupta, Anurag
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Roth, L., Huynh-Russo, L., Heeb, L., Ulugöl, S., Freire Dos Santos, R., Breuer, E., Ungethüm, U., Haberecker, M., Pauli, C., Koelzer, V., Lehmann, K., & Gupta, A. (2024). CD8 + T-cells restrict the development of peritoneal metastasis and support the efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC). Scientific Reports, 14(1), 22324. https://doi.org/10.1038/s41598-024-72826-w
