Publication: Quantitative cell polarity imaging defines leader-to-follower transitions during collective migration and the key role of microtubule-dependent adherens junction formation
Quantitative cell polarity imaging defines leader-to-follower transitions during collective migration and the key role of microtubule-dependent adherens junction formation
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Revenu, C., Streichan, S., Donà, E., Lecaudey, V., Hufnagel, L., & Gilmour, D. (2014). Quantitative cell polarity imaging defines leader-to-follower transitions during collective migration and the key role of microtubule-dependent adherens junction formation. Development, 141(6), 1282–1291. https://doi.org/10.1242/dev.101675
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The directed migration of cell collectives drives the formation of complex organ systems. A characteristic feature of many migrating collectives is a 'tissue-scale' polarity, whereby 'leader' cells at the edge of the tissue guide trailing 'followers' that become assembled into polarised epithelial tissues en route. Here, we combine quantitative imaging and perturbation approaches to investigate epithelial cell state transitions during collective migration and organogenesis, using the zebrafish lateral line primordium as an in vivo mod
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- Revenu, Céline
- Streichan, Sebastian
- Donà, Erika
- Lecaudey, Virginie
- Hufnagel, Lars
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Revenu, C., Streichan, S., Donà, E., Lecaudey, V., Hufnagel, L., & Gilmour, D. (2014). Quantitative cell polarity imaging defines leader-to-follower transitions during collective migration and the key role of microtubule-dependent adherens junction formation. Development, 141(6), 1282–1291. https://doi.org/10.1242/dev.101675
