Publication: Discrete regulation of β-catenin-mediated transcription governs identity of intestinal epithelial stem cells
Discrete regulation of β-catenin-mediated transcription governs identity of intestinal epithelial stem cells
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Borrelli, C., Valenta, T., Handler, K., Vélez, K., Moro, G., Lafzi, A., de Vargas Roditi, L., Hausmann, G., Moor, A. E., & Basler, K. (2020). Discrete regulation of β-catenin-mediated transcription governs identity of intestinal epithelial stem cells (No. 103499; BioRxiv). https://doi.org/10.1101/2020.05.19.103499
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The homeostasis of the gut epithelium relies upon continuous renewal and proliferation of crypt-resident intestinal epithelial stem cells (IESCs). Wnt/β-catenin signaling is required for IESC maintenance, however, it remains unclear how this pathway selectively governs the identity and proliferative decisions of IESCs. Here, we demonstrate that C-terminally-recruited transcriptional co-factors of β-catenin act as all-or-nothing regulators of Wnt-target gene expression. Blocking their interactions with β-catenin rapidly induces loss of
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Borrelli, C., Valenta, T., Handler, K., Vélez, K., Moro, G., Lafzi, A., de Vargas Roditi, L., Hausmann, G., Moor, A. E., & Basler, K. (2020). Discrete regulation of β-catenin-mediated transcription governs identity of intestinal epithelial stem cells (No. 103499; BioRxiv). https://doi.org/10.1101/2020.05.19.103499
