Publication: Uromodulin is expressed in the distal convoluted tubule, where it is critical for regulation of the sodium chloride cotransporter NCC
Uromodulin is expressed in the distal convoluted tubule, where it is critical for regulation of the sodium chloride cotransporter NCC
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Tokonami, N., Takata, T., Beyeler, J., Ehrbar, I., Yoshifuji, A., Christensen, E. I., Loffing, J., Devuyst, O., & Olinger, E. G. (2018). Uromodulin is expressed in the distal convoluted tubule, where it is critical for regulation of the sodium chloride cotransporter NCC. Kidney International, 94(4), 701–715. https://doi.org/10.1016/j.kint.2018.04.021
Abstract
Abstract
Abstract
Uromodulin, the most abundant protein in normal urine, is essentially produced by the cells lining the thick ascending limb. There it regulates the activity of the cotransporter NKCC2 and is involved in sodium chloride handling and blood pressure regulation. Conflicting reports suggested that uromodulin may also be expressed in the distal convoluted tubule (DCT) where its role remains unknown. Using microdissection studies combined with fluorescent in situ hybridization and co-immunostaining analyses, we found a significant expression
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Creators (Authors)
- Tokonami, Natsuko
- Takata, Tomoaki
- Beyeler, Jan
- Ehrbar, Iris
- Yoshifuji, Ayumi
- Christensen, Erik I
- Loffing, Johannes
- Devuyst, Olivier
- Olinger, Eric G
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Citations
Tokonami, N., Takata, T., Beyeler, J., Ehrbar, I., Yoshifuji, A., Christensen, E. I., Loffing, J., Devuyst, O., & Olinger, E. G. (2018). Uromodulin is expressed in the distal convoluted tubule, where it is critical for regulation of the sodium chloride cotransporter NCC. Kidney International, 94(4), 701–715. https://doi.org/10.1016/j.kint.2018.04.021
