C1-inhibitor to prevent intracerebral hemorrhage-related secondary brain injury

Akeret, Kevin; Thomson, Bart R; Ghosh, Subhajit; Nolte, Marc; Fischer, Urs; Humar, Rok; Regli, Luca; Schaer, Dominik J; Hugelshofer, Michael; Buzzi, Raphael M

doi:10.1186/s12987-024-00594-w

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Akeret, K., Thomson, B. R., Ghosh, S., Nolte, M., Fischer, U., Humar, R., Regli, L., Schaer, D. J., Hugelshofer, M., & Buzzi, R. M. (2024). C1-inhibitor to prevent intracerebral hemorrhage-related secondary brain injury. Fluids and Barriers of the CNS, 21(1), 91. https://doi.org/10.1186/s12987-024-00594-w

Abstract

Background Preclinical studies indicate that the systemic application of C1-inhibitor, clinically used to treat hereditary angioedema, reduces secondary brain injury after ischemic stroke. This study assessed the effect of C1-inhibitor on secondary brain injury after hemorrhagic stroke.

Methods We used an established striatal whole-blood injection mouse model to mimic intracerebral hemorrhage-related secondary brain injury. Based on the spatiotemporal dynamics in our model, we calculated the necessary sample size (n = 24) and determi