Associations between white matter hyperintensities, lacunes, entorhinal cortex thickness, declarative memory and leisure activity in cognitively healthy older adults: A 7-year study

Hotz, Isabel; Deschwanden, Pascal Frédéric; Mérillat, Susan; Jäncke, Lutz

doi:10.1016/j.neuroimage.2023.120461

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Hotz, I., Deschwanden, P. F., Mérillat, S., & Jäncke, L. (2023). Associations between white matter hyperintensities, lacunes, entorhinal cortex thickness, declarative memory and leisure activity in cognitively healthy older adults: A 7-year study. NeuroImage, 284, 120461. https://doi.org/10.1016/j.neuroimage.2023.120461

Abstract

INTRODUCTION: Cerebral small vessel disease (cSVD) is a growing epidemic that affects brain health and cognition. Therefore, a more profound understanding of the interplay between cSVD, brain atrophy, and cognition in healthy aging is of great importance. In this study, we examined the association between white matter hyperintensities (WMH) volume, number of lacunes, entorhinal cortex (EC) thickness, and declarative memory in cognitively healthy older adults over a seven-year period, controlling for possible confounding factors. Becau