Publication: In vitro exposure of human fibroblasts to local anaesthetics impairs cell growth
In vitro exposure of human fibroblasts to local anaesthetics impairs cell growth
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Fedder, C., Beck-Schimmer, B., Aguirre, J., Hasler, M., Roth-Z’graggen, B., Urner, M., Kalberer, S., Schlicker, A., Votta-Velis, G., Bonvini, J. M., Graetz, K., & Borgeat, A. (2010). In vitro exposure of human fibroblasts to local anaesthetics impairs cell growth. Clinical and Experimental Immunology, 162(2), 280–288. https://doi.org/10.1111/j.1365-2249.2010.04252.x
Abstract
Abstract
Abstract
Lidocaine, bupivacaine or ropivacaine are used routinely to manage perioperative pain. Sparse data exist evaluating the effects of local anaesthetics (LA) on fibroblasts, which are involved actively in wound healing. Therefore, we investigated the effects of the three LA to assess the survival, viability and proliferation rate of fibroblasts. Human fibroblasts were exposed to 0·3 mg/ml and 0·6 mg/ml of each LA for 2 days, followed by incubation with normal medium for another 1, 4 or 7 days (group 1). Alternatively, cells were incubate
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- Fedder, C
- Beck-Schimmer, B
- Aguirre, J
- Hasler, M
- Roth-Z'graggen, B
- Urner, M
- Kalberer, S
- Schlicker, A
- Votta-Velis, G
- Bonvini, J M
- Graetz, K
- Borgeat, A
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Fedder, C., Beck-Schimmer, B., Aguirre, J., Hasler, M., Roth-Z’graggen, B., Urner, M., Kalberer, S., Schlicker, A., Votta-Velis, G., Bonvini, J. M., Graetz, K., & Borgeat, A. (2010). In vitro exposure of human fibroblasts to local anaesthetics impairs cell growth. Clinical and Experimental Immunology, 162(2), 280–288. https://doi.org/10.1111/j.1365-2249.2010.04252.x
