Amino acid changes in the spike protein of feline coronavirus correlate with systemic spread of virus from the intestine and not with feline infectious peritonitis

Porter, E; Tasker, S; Day, M J; Harley, R; Kipar, A; Siddell, S G; Helps, C R

doi:10.5167/uzh-95860

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Porter, E., Tasker, S., Day, M. J., Harley, R., Kipar, A., Siddell, S. G., & Helps, C. R. (2014). Amino acid changes in the spike protein of feline coronavirus correlate with systemic spread of virus from the intestine and not with feline infectious peritonitis. Veterinary Research, 45, 49. https://doi.org/10.1186/1297-9716-45-49

Abstract

Recent evidence suggests that a mutation in the spike protein gene of feline coronavirus (FCoV), which results in an amino acid change from methionine to leucine at position 1058, may be associated with feline infectious peritonitis (FIP). Tissue and faecal samples collected post mortem from cats diagnosed with or without FIP were subjected to RNA extraction and quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) to detect FCoV RNA. In cats with FIP, 95% of tissue, and 81% of faecal samples were PCR-positive, as opp