Publication: In vitro and ex vivo proteomics of Mycobacterium marinum biofilms and the development of biofilm-binding synthetic nanobodies
In vitro and ex vivo proteomics of Mycobacterium marinum biofilms and the development of biofilm-binding synthetic nanobodies
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Hammarén, M. M., Luukinen, H., Sillanpää, A., Remans, K., Lapouge, K., Custódio, T., Löw, C., Myllymäki, H., Montonen, T., Seeger, M., Robertson, J., Nyman, T. A., Savijoki, K., & Parikka, M. (2023). In vitro and ex vivo proteomics of Mycobacterium marinum biofilms and the development of biofilm-binding synthetic nanobodies. MSystems, 8(3), e0107322. https://doi.org/10.1128/msystems.01073-22
Abstract
Abstract
Abstract
The antibiotic-tolerant biofilms present in tuberculous granulomas add an additional layer of complexity when treating mycobacterial infections, including tuberculosis (TB). For a more efficient treatment of TB, the biofilm forms of mycobacteria warrant specific attention. Here, we used Mycobacterium marinum (Mmr) as a biofilm-forming model to identify the abundant proteins covering the biofilm surface. We used biotinylation/streptavidin-based proteomics on the proteins exposed at the Mmr biofilm matrices in vitro to identify 448 prot
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Creators (Authors)
- Hammarén, Milka Marjut
- Luukinen, Hanna
- Sillanpää, Alina
- Remans, Kim
- Lapouge, Karine
- Custódio, Tânia
- Löw, Christian
- Myllymäki, Henna
- Montonen, Toni
- Seeger, Markus
- Robertson, Joseph
- Nyman, Tuula A
- Savijoki, Kirsi
- Parikka, Mataleena
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Citations
Hammarén, M. M., Luukinen, H., Sillanpää, A., Remans, K., Lapouge, K., Custódio, T., Löw, C., Myllymäki, H., Montonen, T., Seeger, M., Robertson, J., Nyman, T. A., Savijoki, K., & Parikka, M. (2023). In vitro and ex vivo proteomics of Mycobacterium marinum biofilms and the development of biofilm-binding synthetic nanobodies. MSystems, 8(3), e0107322. https://doi.org/10.1128/msystems.01073-22
