Publication: MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes
MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes
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Freyre, C. A. C., Rauher, P. C., Ejsing, C. S., & Klemm, R. W. (2019). MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes. Molecular Cell, 76(5), 811-825.e14. https://doi.org/10.1016/j.molcel.2019.09.011
Abstract
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Abstract
Physical contact between organelles is vital to the function of eukaryotic cells. Lipid droplets (LDs) are dynamic organelles specialized in lipid storage that interact physically with mitochondria in several cell types. The mechanisms coupling these organelles are, however, poorly understood, and the cell-biological function of their interaction remains largely unknown. Here, we discover in adipocytes that the outer mitochondrial membrane protein MIGA2 links mitochondria to LDs. We identify an amphipathic LD-targeting motif and revea
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- Freyre, Christophe A C
- Rauher, Pascal C
- Ejsing, Christer S
- Klemm, Robin W
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Freyre, C. A. C., Rauher, P. C., Ejsing, C. S., & Klemm, R. W. (2019). MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes. Molecular Cell, 76(5), 811-825.e14. https://doi.org/10.1016/j.molcel.2019.09.011