Publication: The ghrelin receptor agonist HM01 mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats
The ghrelin receptor agonist HM01 mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats
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Borner, T., Loi, L., Pietra, C., Giuliano, C., Lutz, T. A., & Riediger, T. (2016). The ghrelin receptor agonist HM01 mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 311(1), R89–R96. https://doi.org/10.1152/ajpregu.00044.2016
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The gastric hormone ghrelin positively affects energy balance by increasing food intake and reducing energy expenditure. Ghrelin mimetics are a possible treatment against cancer anorexia-cachexia syndrome (CACS). This study aimed to characterize the action of the nonpeptidergic ghrelin receptor agonist HM01 on neuronal function, energy homeostasis and muscle mass in healthy rats and to evaluate its possible usefulness for the treatment of CACS in a rat tumor model. Using extracellular single-unit recordings, we tested whether HM01 mim
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- Borner, Tito
- Loi, Laura
- Pietra, Claudio
- Giuliano, Claudio
- Lutz, Thomas A
- Riediger, Thomas
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Borner, T., Loi, L., Pietra, C., Giuliano, C., Lutz, T. A., & Riediger, T. (2016). The ghrelin receptor agonist HM01 mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 311(1), R89–R96. https://doi.org/10.1152/ajpregu.00044.2016
