Publication: How stemlike are sphere cultures from long-term cancer cell lines? Lessons from mouse glioma models
How stemlike are sphere cultures from long-term cancer cell lines? Lessons from mouse glioma models
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Ahmad, M., Frei, K., Willscher, E., Stefanski, A., Kaulich, K., Roth, P., Stühler, K., Reifenberger, G., Binder, H., & Weller, M. (2014). How stemlike are sphere cultures from long-term cancer cell lines? Lessons from mouse glioma models. Journal of Neuropathology and Experimental Neurology, 73(11), 1062–1077. https://doi.org/10.1097/NEN.0000000000000130
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Cancer stem cells may mediate therapy resistance and recurrence in various types of cancer, including glioblastoma. Cancer stemlike cells can be isolated from long-term cancer cell lines, including glioma lines. Using sphere formation as a model for cancer cell stemness in vitro, we derived sphere cultures from SMA-497, SMA-540, SMA-560, and GL-261 glioma cells. Gene expression and proteomics profiling demonstrated that sphere cultures uniformly showed an elevated expression of stemness-associated genes, notably including CD44. Differ
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- Ahmad, M
- Frei, K
- Willscher, E
- Kaulich, K
- Roth, P
- Reifenberger, G
- Binder, H
- Weller, M
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Ahmad, M., Frei, K., Willscher, E., Stefanski, A., Kaulich, K., Roth, P., Stühler, K., Reifenberger, G., Binder, H., & Weller, M. (2014). How stemlike are sphere cultures from long-term cancer cell lines? Lessons from mouse glioma models. Journal of Neuropathology and Experimental Neurology, 73(11), 1062–1077. https://doi.org/10.1097/NEN.0000000000000130
