A population-based approach to assess the heritability and distribution of renal handling of electrolytes

Moulin, Flore; Ponte, Belen; Pruijm, Menno; Ackermann, Daniel; Bouatou, Yassine; Guessous, Idris; Ehret, Georg; Bonny, Olivier; Pechère-Bertschi, Antoinette; Staessen, Jan A; Paccaud, Fred; Martin, Pierre-Yves; Burnier, Michel; Vogt, Bruno; Devuyst, Olivier; Bochud, Murielle

doi:10.1016/j.kint.2017.06.020

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Moulin, F., Ponte, B., Pruijm, M., Ackermann, D., Bouatou, Y., Guessous, I., Ehret, G., Bonny, O., Pechère-Bertschi, A., Staessen, J. A., Paccaud, F., Martin, P.-Y., Burnier, M., Vogt, B., Devuyst, O., & Bochud, M. (2017). A population-based approach to assess the heritability and distribution of renal handling of electrolytes. Kidney International, 92(6), 1536–1543. https://doi.org/10.1016/j.kint.2017.06.020

Abstract

The handling of electrolytes by the kidney is essential for homeostasis. However, the heritability of these processes, the first step in gene discovery, is poorly known. To help clarify this, we estimated the heritability of serum concentration, urinary excretion, renal clearance, and fractional excretion of sodium, potassium, magnesium, calcium, phosphate, and chloride in a population-based study. Nuclear families were randomly selected from the general population in Lausanne, Geneva, and Bern, Switzerland, and urine collected over 2